Impact of androgen

The androgenic hormones can have a major influence on hair loss in women. In this case, we explain the details of metabolism that occurs while in the hair follicle. This is to better understand how the treatments will be able to neutralize it.

1 – Women and androgens
2 – Androgens in the hair follicle
3 – The impact genetic
4 – Observation biological
5 – Processing inhibitor

Women and androgens

1 Androgen is the generic term for all male sex hormones. These hormones (the main of which is testosterone) are responsible for most of the problems with the hair in humans, but also in women.
2 Explanation: Our hair grows and live under hormonal dependence. For women, the female sex hormones, estrogen and progesterone, are the main factors of development. But women produce, too, testosterone, though in quantity 20 times less than men. If constitutional predisposition, this small amount is secreted by the adrenal glands (60%) and their ovaries (40%), which can exert a negative influence on the normal renewal of their hair.
3 However, unlike men, women never become bald because their emissions of androgens are thwarted by those of estrogen, functionally anti-androgens.

Androgens in the hair follicle

1 Testosterone comes by the blood to hair follicles. There, it binds to receptors, the Androgen Receptor (AR), present on the four key sites for the manufacture of hair:
- The papilla through which the blood arrives
- The matrix that generates the keratin cells and transforms them into hair
The follicle-sheath that serves as guardian of the hair shaft formation,
- The sebaceous gland, finally, which is entirely under the control of androgen.

2 As soon as it passes through its target receptor, testosterone binds immediately to an enzyme (5 alpha-reductase), which metabolizes into a new androgen, DHT (dihydrotestosterone).

3 Of a healthy follicle, the two substances combine consequences and do not interfere in any way the physiological development of male hair.

The impact genetic

1 Problems arise when genetic predisposition: there is then a mutation of the follicle under the influence of negative one or more genes called alopecia.

2 Cascading consequences: Genes alopecic generate an overactive 5-reductase, which in turn triggers increased secretion of DHT, which in turn upsets the work faster and the hair follicles, leading to their gradual degradation and night, finally, the development normal hair.

3 The genes of alopecia can be transmitted to a daughter, by the genetic code of his mother or his father, or both at once. This does not mean that the child, whose gene pool has this legacy, has itself always tends to lose his hair later … Because nothing is simple in genetics: a child may carry genes without them never wake up. This will depend in part on his land, that is to say all of their personal data, both physiological and psychological, which will promote or not the development of the disorder.

4 It’s not the amount of testosterone secreted is in question (except in rare cases of severe hirsutism) but the more or less “greedy” in which it is captured and transformed by the genetically programmed follicles . In other words, it is not usually a hormonal disorder, but local, limited to the hair follicle. This is a “disease of the receiver,” the medical term.

5 To date, several teams of geneticists around the world are working to isolate the genes of alopecia. When they arrive there, the disorder should be eradicated by androgenesthérapie gene.

Observation 4 Organic

1 The observation of biological damage caused by this genetic disruption, has made good progress over the past 10 years. By incorporating the four key sites where the head 5 a-reductase in the hair follicle, we now know how faulty this enzyme triggers the attack all fronts … confused!

A – The disc shrinks, blood flow is reduced: the follicle will gradually miniaturized.

B – The Matrix, less well-irrigated and disturbed his rhythm, his time reduces production of keratin: the hair that will follow will be developed too quickly, too quickly renewed and more sickly, with each renewal.

C – The cells of the outer root sheath differ more difficult: the stem less firmly anchored in formation to the follicle.

D – In this structure less well differentiated, the secretion of sebum can invade the interior of the hair follicle instead of vented to the outside of the skin: the infiltration of the root asphyxiation sebaceous residues, which contribute to the narrowing again.
racineracine

2 It is therefore a constitutional and excessive responsiveness of the follicle to androgens which causes this type of alopecia. The consolidation of the two terms “gene” and “androgen,” said one of androgenetic hair loss.
Left: Racine normal, well-watered
Right: Root androgenetic, malnourished and suffering

Treatment 5 inhibitors

1 According to our statistics, the best results are obtained by combining a local treatment Clauderer an anti-androgen hormone therapy, oral. The first cleanses the hair follicles and roots gives compensatory vitamins, essential for the anchoring of the hair and the vigor of regrowth. The second (if deemed appropriate, after liendu diagnosis of root and the hair keratin, weakens the binding testosterone-5 alpha-reductase and reduces the secretion of DHT.

2 Important. For those who can not or will not take hormone therapy, the treatment Clauderer local, thanks to a complex 100% natural plant anti-androgens and essential oils targeted often enough to neutralize the activity of a 5 reductase and to stop hair loss.